Rental Tubular Acidosis Pearl -cont-

 


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A 58-year-old male is brought into the emergency room by his family. The patient’s family claims that he has been confused and has had difficulty walking for the past two weeks. 

Past medical history: none 
Medication:None 
No known drug allergy 
Social history: Chronic alcohol, no tobacco or intravenous drug abuse 

The exam reveals that both eyes are unable to look laterally and he also has a severe ataxia. You realize that this patient has Wernickes encephalopathy possibly progressing into Korsakoff’s syndrome. What should you do? 

(A) MRI to rule out other organic causes 
(B) Intravenous vitamin B12, this patient has severe B12 deficiency 
(C) Intravenous thiamine 
(D) Intravenous folate 
(E) Intravenous dilantin 

B; This 17 year old female has iron deficiency anemia, probably from dietary deficiency as well as increased blood loss through menses. This disorder is usually easily treated with iron supplementation in the form of ferrous sulfate. Transfusion is unnecessary. In Folate deficiency the anemia is macrocytic and iron studies are normal. 

C; A young patient with abnormal liver function and psychiatric disorder should raise the suspicion of Wilson’s disease. The classic ocular finding is the brown green or yellow brown pigmentation around the periphery of the cornea. (See Wilson’s Disease Pearl for more detail). 

A, Although this patient seemingly has many cardiac risk factors, he does not have any of the high risk variables (critical AS, decompensated CHF, MI <6 months, significant arrhythmia). The Goldman-Detsky risk index is low (zero points). Because this is a vascular surgical procedure, the intermediate and low risk variables must also be considered. Of these, the patient only has diabetes. Although the BP is mildly elevated, he does not have a known history of hypertension and it is not “uncontrolled” (repeatedly elevated despite intervention or with signs of end organ damage such as LVH, MI, CVA). Although his functional capacity is limited by claudication, he works as an auto mechanic and is presumably able to do more than 4 METS of activity. Therefore, he is at low risk of cardiac complications and can proceed directly with surgery. A treadmill stress test is not indicated in a patient limited by claudication. A resting echocardiogram has no utility in predicting peri-operative cardiac risk. Although beta-blockers are proven beneficial in lowering peri-operative cardiac risk, this patient has no clear indication for use and a relative contra-indication (COPD). 

C; Primary amenorrhea is defined as no menses and lack of other secondary sexual development signs by age 14 or lack of menses with normal development of breast and pelvic hair by age 16. This patient does not meet this definition and hence does not need a work-up for amenorrhea at this time. However, it is always important to rule out pregnancy. Once pregnancy is ruled out reassuring the patient would be appropriate. 

B; This patient has atrial flutter with a rapid ventricular response which requires control. His stable hemodynamic status makes this case less urgent and immediate defibrillation is not required. Since the Pt has had no prior cardiac history, it is likely that the current arrhythmia is of less than 48hr duration and thus anticoagulation is not required at this time. Giving more adenosine will only be a transient solution since adenosine has such a short half-life. The best way to control this patient’s cardiac rate is with a calcium channel blocker like diltiazem.

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